Regional airline Flybe will start serving seven new destinations this summer, but has been forced to stop its Leeds-Gatwick service.
The move means Leeds Bradford Airport will lose its only London link at the end of this month.
Flybe said the decision to scrap the route was due to insufficient numbers and external cost pressures – largely due to a rise in landing fees at Gatwick airport.
A Flybe spokeswoman said: “The suspension of this route is a direct consequence of the policies being implemented by Gatwick to limit the number of smaller, regional aircraft landing at their airport.”
Gatwick has opted to “raise substantially” the landing fees for regional aircraft, she said, but not for larger aircraft.
“More than 50,000 passengers flew from Leeds Bradford to London Gatwick with Flybe in 2010. They have now been deprived of a link to the capital because of the charging regime being adopted by Gatwick’s new owners.”
From April 19, Flybe will start new three-time-weekly services to Edinburgh from Knock, followed by the launch of weekly Exeter-Dusseldorf flights from April 23.
Five-times weekly flights between Manchester and the City of Derry will start from May 19, and from May 26 Flybe will offer a three-times-weekly service from Belfast City to Manston.
Flybe has also mapped out significant expansion from Southampton, with three new summer only routes: Clermont Ferrand from May 21 to September 24; Beziers from May 27 to September 23; and Pau from May 25 to September 25.