Air France dropping its daily flights from London Heathrow to Los Angeles from the end of October, seven months after the route was launched.
The route was introduced in March following the Open Skies agreement, but Air France says it will be removed from the winter schedule.
Air France said it is part of the "optimisation of the Skyteam transatlantic network on departure from London Heathrow".
The carrier says the slot and aircaft will be used for a daily flight from Heathrow to New York JFK, although not until the summer 2009 schedule.
This will increase Skyteam's offering on the route to three flights per day, with Delta already flying the route twice-daily.
Current Skyteam member Continental serves Heathrow from New York Newark, although the carrier is defecting to rivals Star Alliance next year.
Air France will rebook passengers due to travel from London to LA between November 6-30, December 19-21 and January 1-6, 2009, on flights via Paris CDG for the same dates and in the same booking class.
Those travelling outside these dates need to contact their travel agent or Air France's UK call centre. A full refund is available.
Visit www.airfrance.co.uk.
Mark Caswell