Lufthansa is switching its Berlin service from London City Airport to Heathrow to allow the route to be operated by an Airbus 319.
The move, which will increase capacity on the route by over 50%, forms part of Lufthansa's summer timetable.
The new timetable also sees the seasonal return of a third daily frequency between Edinburgh and Frankfurt, and the introduction of an Inverness-Düsseldorf from 20 June to 12 September.
In addition, new flights will be offered by start-up Lufthansa Italia between Heathrow and Milan Malpensa.
Passengers from the UK will be able to take advantage of a number of new connections via Germany, with the introduction of Rzeszów in southeast Poland (five times a week from 27 April), a daily Frankfurt-Poznan service in addition to the daily flight from Munich, and a daily connection from Munich to Lviv in Ukraine.
Lufthansa will also add a new daily connection from Düsseldorf to Venice on 20 April and at weekends will operate from Munich to Split and Dubrovnik.
Frequencies on connections to Madrid, Stavanger, Nizhny Novgorod and Perm (Russia) will be increased.
Munich-Tel Aviv will return to four times a week, while Jeddah and Riyadh will each be served by a daily non stop flight from Frankfurt and there will also be daily flights to Muscat and Addis Ababa.
Frequencies will be added to Algiers, Sana in Yemen, Dubai and Mumbai.
‘The new and improved connections offered by the summer timetable show the importance of the UK market to Lufthansa even in the current economic climate,' commented Marianne Sammann, Lufthansa general manager UK & Ireland.
‘Despite the suspension of our service between Bristol and Frankfurt, Lufthansa will still have a presence in the South West following the introduction of the new bilateral code sharing between Lufthansa and Brussels Airlines. So, the vast majority of our UK passengers will have more and even better connections to a wide range of destinations.
‘At the same time, our portfolio is growing with the new Lufthansa Italia offer from Heathrow. Bookings for the new service are growing at a rate of well over 1000% since January, an excellent take up of our now increased offer of six daily flights from London to Milan.'
Lufthansa's summer schedule offers a total of 14,038 weekly flights providing UK passengers with connections to 206 destinations in 78 countries worldwide.
The airline also announced changes to its on-board product, with two of the three Lufthansa Business Jets operated for Lufthansa by PrivateAir having economy class seats added.
The reconfigured aircraft will be introduced on Frankfurt-Bahrain and Frankfurt-Dammam in September, offering 32 seats in business and 60 in economy.