Easyjet is dropping its Gatwick to Moscow route due to a lack of demand driven by weakness in the Russian economy.
The service will end in March next year but will be kept under review and restored if there is an increase in demand.
The airline also highlighted a tightening of the visa approval process, due to economic sanctions placed on Russia, as a reason why the route has been stopped.
"The decision has been taken in response to the significant and sustained reduction in demand for travel,” Easyjet said in a statement.
The airline only began flying to Moscow in 2013 when it beat Virgin Atlantic to win the rights to operate between the two countries.
Last week, Russian flag carrier Aeroflot, which also operates on the Gatwick-Moscow route, announced it will acquire rival airline Transaero for a 75 per cent stake in the struggling carrier.