Irish carrier Aer Lingus will stop flights to New York and Boston from Shannon from January 5, due to "significant losses".
The suspension, which affects eight flights per week, will last for five weeks, ending on March 27.
The airline said the decision came after a "detailed review of route profitability".
After March 27, for the remaining nine months of the year, Aer Lingus will continue its four flights per week between Shannon and New York and a further four flights per week between Shannon and Boston.
Since 1995 Aer Lingus has lost a total of €163 million on its transatlantic flights from Shannon during the winter months with an average operating loss per winter season of almost €11 million, said the airline.
Christoph Mueller, Aer Lingus' CEO, said: "Aer Lingus is committed to the Shannon market as an important part of our network.
"However, in order to maintain the viability of our Shannon transatlantic operations throughout the remainder the year, the 3 month suspension of these routes when seasonal demand is at its lowest is crucial."
www.aerlingus.com