From July 15, Flybe will start flights between London Gatwick and Nantes.
The six-times weekly service will depart Gatwick at 12.25pm, arriving into Nantes at 2.50pm. The return flight leaves Nantes at 3.30pm, to arrive at Gatwick at 3.55pm.
Mike Rutter, Flybe's chief commercial officer, said: "We have an enviable reputation for serving regional France* and our new route linking London Gatwick with Nantes demonstrates our ongoing commitment to expanding our route network and to providing innovative, quality travel options to key destinations."
As Brittany's commercial hub, Nantes is the sixth largest city in France.
Flybe is also launching flights from London Gatwick to Limoges from July 13.