From September 1 Emirates will serve Manchester Airport with an Airbus A380.
The B777 currently used for flights EK017 and EK018 will be replaced by the superjumbo, arriving into Manchester daily at11.45 before departing at 1.30pm.
The Manchester services will also be the world's most northerly deployment of an A380, said Emirates.
The super size airliner will boost capacity on the route by 75 seats a day.
Tim Clark, Emirates' president, said: "Manchester has been one of the strongest performers in our growing network of regional gateways, not only in the UK but globally as well.
"Our customers value our commitment to a regional network at a time when other airlines are abandoning them.
"This is a ground-breaking announcement for the airport and its global standing. It is a well-deserved boost for our loyal and growing customer base in the North West."
Andrew Cornish, Manchester Airport's managing director, said: "We have invested close to £10 million in upgrading the airfield and terminal both to accommodate the aircraft itself and to create a fitting environment for Emirates' customers, whether it is at check-in, using the airline's executive lounge or at the gate area.
"The A380 is as iconic as Concorde and her introduction into Manchester by one of our most important carriers, Emirates, will provide a daily reminder that regional airports can support successful long-haul services."
Emirates has been flying between Manchester and Dubai since 1990, carrying more than 4 million passengers to and from north west England.
www.emirates.com/uk