Air France subsidiary Cityjet is to drop its Manchester-Antwerp service from mid-September.
The route is currently the only Cityjet service from Manchester airport, and the only non-stop service by any carrier between Manchester and the Belgian city.
Cityjet serves the route six times-weekly using Fokker 50 aircraft but the route will be scrapped from September 17.
The company confirmed that the route would end next month on its official Twitter page and said more information was available for customers by emailing customercare@cityjet
The carrier also serves the Belgian city from London City, with up to five flights per day, also using Fokker 50 aircraft.
cityjet.com