Airlines are struggling to survive and massive changes are needed, Giovanni Bisignani told The International Air Transport Association (IATA) at its its annual meeting in Istanbul.In his state of the industry address, Mr Bisignani said governments, industry partners and workforces must help the carriers. "Airlines are struggling for survival and massive changes are needed. Governments must stop crazy taxation, change the rules of the game and fix the infrastructure."Labour must understand that jobs disappear if costs don't come down. And to our partners, the message is simple. We are in this together. Don't bite the hand that feeds you," Mr Bisignani, president and ceo of IATA, said.He said based on an average price of fuel of $106.5 per barrel, the industry was heading for a $2.3bn loss this year.If oil were to rise to $135 per barrel, that loss would be potentially $6.1bn."Over the last 60 years the industry made $11.5 trillion in revenues, but only $32bn in profits. Average margin for the entire industry has been just 0.3%."And the industry is $190bn in debt. Since 2001, airlines achieved massive change. Fuel efficiency improved 19% and non-fuel unit costs dropped 18%. "The skyrocketing price of oil has eaten these gains and left the industry in the red again. Oil prices at US$130 a barrel are changing the game for everyone. The situation is grim," he said. Mr Bisignani said the industry had to make governments aware of the “dimension of the oil crisis, the potential impact on the global economy if the air transport industry fails, the measures that airlines are taking to survive and the action we need from them.”To help achieve this, IATA is organising an Agenda for Freedom Summit in Istanbul in the fourth quarter of this year with an open invitation to all countries to attend.Mr Bisignani said there had been two solid areas of progress: safety and simplifying the business.But there were three other areas where changes were needed: security, regulation of monopolies and the environment.He said security was an "uncoordinated mess" with passengers facing a maze of bureaucracy and hassle.On monopolies, he said there were still too many monopolies suppliers isolated from commercial discipline.Mr Bisignani said the current fuel crisis "must be a catalyst for governments to deliver results on environment that reduce fuel burn."