Lufthansa has called for further talks with union group Vereinigung Cockpit to try and avoid three-day strike action this week.
Pilots at Germany's largest airline recently announced they would strike over pay and contract negotiations and have now confirmed the strike will go ahead from 2200 GMT on April 1 until 2159 GMT on April 4.
The German carrier said its willing to continue the talks at any time to try and resolve the issue and "will do everything to take care of those affected".
"We greatly regret the fact that this strike may prevent us from bringing our passengers to their destination or back home on time," said Lufthansa's chief human resources officer, Bettina Volkens.
"With the goodwill of everyone involved, we should be able to avoid a strike.
"Wherever possible, we will offer alternative travel options. At the same time, we are still working to solve the collective bargaining dispute,” she added.
VC, which represents around 5,400 Lufthansa pilots, said on Friday it had tried to offer suggestions to resolve the pay row but that the airline had not taken up the offer seriously.
"We won't let ourselves be given the run-around by Lufthansa," VC board member Ilona Ritter said in a statement on Friday.
More than 99 percent of the pilots had voted in favor of strike action to resolve the transition contract issue in a ballot.
Last week Lufthansa cancelled around 600 flights due to a strike by public sector workers employed in areas such as baggage handling at German airports.