Omega World Travel has formed a partnership with Italian-based travel management company Seneca Business Travel.
Alan Farmer, head of marketing and overseas development, said the aim was to serve pan-European partners.
Mr Farmer, speaking at a press conference in Rome at the Association of Corporate Travel Executives' global education conference, said the tie up would bring "massive savings" to clients.
He said Omega was among the biggest four TMCs in America and in the Top 20 in the UK.
Omega is also a founder member of Radius Travel, a global network of TMCs.
Visit www.omegatravel.co.uk and www.senecabusinesstravel.com.