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Eurostar will be unable to operate trains to Brussels on Sunday evening (October 17) and most of Monday (October 18), due to a 24-hour strike in Belgium.
The walk-out is due to start at 10pm on Sunday, and end at 10pm on Monday.
The cross-channel rail operator has warned that the industrial action will force Brussels Midi train station to close, along with the rest of the Belgian rail network.
Eurostar said it will be operating a limited coach service between Brussels and Lille in France, but warned this would mean increase by around two hours.
Customers are advised to postpone their journeys - tickets can be exchanged free of charge within 60 days for a journey in the following 120 days.
Services to Ebbsfleet International, Ashford International and Paris will continue as normal, although many may include an un-timetabled stop at Lille.